Natural Home Cures Freeze Dried Rich Pericarp Mangosteen May Help in Address Parkinson's Disease Naturally


Parkinson's disease (PD) is a degenerative disorder of the central nervous system. It affects neurons that control movement.  It leads to impairments in the sufferer's motor skills, speech, and other functions.

Parkinson's belongs to a group of neurologic conditions called motor system disorders. It is a consequence of the insufficient formation and action of dopamine by dopaminergic neurons in the substantia nigra of the brain. Dopamine normally transmits signals that help coordinate movement. The mechanism that results in the damages of these cells remains unknown.

As Parkinson's progress, patients may experience difficulty walking, talking or accomplishing simple tasks. The disease usually affects people over the age of 50, and it is more common in men than women.

The early symptoms are subtle and develop slowly, but in some patients, the disease can progress more quickly. Moreover, while some patients become severely disabled, others only experience minor motor impairments. To date, no blood or laboratory tests have been developed to help in diagnosing Parkinson's accurately. 

In most cases, the diagnosis is based on medical history and neurological evaluation.  The disease is difficult to diagnose accurately so doctors may request brain scans such as CT scan or MRI and laboratory tests to rule out other conditions.

Parkinson's Disease Symptoms

Parkinson's disease has four primary symptoms:
Tremors: trembling of the hands, arms, legs, jaw, and face which is more evident when the limb is at rest and disappears with voluntary movement and sleep.

Rigidity: stiffness of the arms, legs, and trunk due to joint stiffness and increased muscle tone and usually associated with joint pain.

Postural Instability: poor balance and coordination that, in the advanced stages can lead to falls; It is also the symptom that is least responsive to treatment.

Bradykinesia: slowness of movement; the most characteristic clinical feature of the disease and it causes difficulties with planning, initiation, and execution of movement.

Other symptoms of Parkinson's include a mask-like facial expression, small handwriting (micrographia), depression,  urinary problems, skin problems, difficulty in swallowing (dysphagia), chewing, speaking and sleep disturbances. Gait and posture may also be affected such as decreased arm swing, a stooped posture and the use of small steps when walking.

Parkinson's Disease Treatment

There is no cure for Parkinson's, but a variety of medications provides relief from symptoms.  Patients are usually given levodopa combined with carbidopa. 

Carbidopa is a dopa decarboxylase inhibitor that delays the conversion of levodopa into dopamine until it reaches the brain.  Dopaminergic neurons can utilize levodopa to make dopamine and replenish the brain's supply.  While levodopa is effective in at least three-quarters of patients, not all symptoms respond equally to the medication.

Bradykinesia and rigidity respond favorably while tremor may be only slightly reduced. Balance and other symptoms may show no response at all.  Anticholinergics may help control tremor and rigidity.  Dopamine agonists are also used to mimic the role of dopamine in the brain, causing the neurons to react as they would to dopamine. However, these medications have known side effects such as somnolence, hallucinations, and insomnia.

In some cases, surgery may be indicated if the disease fails to respond to medication. Also, a therapy called deep brain stimulation (DBS) has gained the approval of the U.S. Food and Drug Administration. DBS can reduce the need for levodopa and other medications, which in turn reduces involuntary movements that are a common side effect of levodopa. DBS also helps to reduce tremors, bradykinesia and gait difficulties.

Mangosteen May Help for Parkinson's Disease

Parkinson's is one of those idiopathic forms of the disease that leave their victims wondering what could contribute to improving their condition. Medications do help, but they may have adverse side effects. There are many promising pharmaceutical remedies that are going through further studies and clinical trials, but one excellent natural alternative is the mangosteen.

Mangosteen supplements are being integrated into the treatment regimen of patients who have Parkinson's. The secret to the healing properties of mangosteen lies on a group of compounds called xanthones.

They are among the most potent antioxidants known to man. This property is of utmost importance about Parkinson's because it is a known fact that oxidative damage to the brain is a significant cause of the disease and other neurologic disorders. Because mangosteen is one of the best antioxidants on the planet, it may be effective in addressing mental degeneration, and it has been shown to assist with mental acuity.

Xanthones as an antioxidant are five times more potent than vitamins C and E. It is this antioxidant property of mangosteen that is sparking the interest among scientists trying to crack the code for a cure for Parkinson's.

The dopaminergic neurons in the brain's substantia nigra that produce dopamine are susceptible to free radical damage, much like any other cells in the human body. The antioxidant properties of xanthones protect those neurons that produce dopamine, enabling patients to get relief from the scourge of Parkinson's.

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Source References

  • "Symptomatic pharmacological therapy in Parkinson’s disease." Parkinson's Disease. London: Royal College of Physicians. ISBN 1-86016-283-5.
  • "Deep Brain Stimulation for Parkinson Disease: An Expert Consensus and Review of Key Issues".
  • The National Collaborating Centre for Chronic Conditions: "Non-motor features of Parkinson’s disease." Parkinson's Disease. London: Royal College of Physicians. ISBN 1-86016-283-5.
  • "Cellular replacement therapy for Parkinson's disease--where we are today?". The Neuroscientist
  • Stem Cell Research Aims to Tackle Parkinson's Disease".

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